Terion Stewart rushed for 170 yards and two second-half touchdowns as Bowling Green gained 221 yards on the ground. Broden had two TD catches and 110 yards receiving while Sims made five catches for 103 yards.
McDonald completed eight of his first 11 passes with two touchdowns to Christian Sims, for 81 and 6 yards - and a third to Tyrone Broden. McDonald's run for the final touchdown appeared to be set up as a kneel-down when he saw a gap and bolted out of the pocket.
The Falcons (3-6, 1-4 Mid-American Conference) ended a four-game skid. The teams amassed 983 yards of total offense. The teams combined for 49 points in the fourth quarter alone, matching score for score, and Buffalo rallied with 34 points after halftime. McDonald entered the game with six touchdown passes on the season. Matt McDonald threw for 263 yards and a career-best four touchdowns - three in the first half - ran 47 yards for the capper with under a minute to play and Bowling Green survived the ejection of head coach Scot Loeffler to upend Buffalo 56-44 on Saturday.